Evaluation of genetic diversity in dog breeds using pedigree and molecular analysis: A review.
Mabunda, Ripfumelo Success ; Makgahlela, Mahlako Linah ; Nephawe, Khathutshelo Agree ; Mtileni, Bohani
Mabunda, Ripfumelo Success
Makgahlela, Mahlako Linah
Nephawe, Khathutshelo Agree
Mtileni, Bohani
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Abstract
Domestic dogs are important for many economic and social reasons, and they have become a well-known model species for human disease. According to research, dog breeds exhibit significant levels of inbreeding and genetic diversity loss, decreasing the population’s ability to adapt in certain conditions, and indicating the need of conservation strategies. Before the development of molecular markers, pedigree information was used for genetic diversity management. In recent
years, genomic tools are frequently applied for accurate estimation of genetic diversity and improved genetic conservation due to incomplete pedigrees and pedigree errors. The most frequently used molecular markers include PCR-based microsatellite markers (STRs) and DNA sequencing-based single-nucleotide polymorphism markers (SNP). The aim of this review was to highlight genetic diversity studies on dog breeds conducted using pedigree and molecular markers, as well as the importance of genetic diversity conservation in increasing the adaptability and survival of dog breed populations.
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Date
2022-11-29
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Publisher
MDPI
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Keywords
Genetic conservation, Genetic diversity, Microsatellite markers, Pedigree information, Single-nucleotide polymorphism markers