Nano-scale drug delivery systems for carboplatin: A comprehensive review
Pourmadidi, Mehrab Eshaghi, Mohammad Mahdi Shaghaghi, Meysam Das, Sabya Sachi Arshad, Rabia Ghotekar, Suresh Rahdar, Abbas Manicum, Amanda-Lee Pandey, Sadanand
Pourmadidi, Mehrab
Eshaghi, Mohammad Mahdi
Shaghaghi, Meysam
Das, Sabya Sachi
Arshad, Rabia
Ghotekar, Suresh
Rahdar, Abbas
Manicum, Amanda-Lee
Pandey, Sadanand
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Abstract
Hepatocellular carcinoma (HCC) is recognized as a global health issue accounting for millions of deaths every year. Surgery, liver ablation, and embolization therapy are amongst the conventional methods for treatment of HCC. Chemotherapy plays a major role in HCC therapy, however, owing to its conventional pharmacotherapy limitations, it necessitates the development of novel therapeutic strategies. In contrast, nanomedicines for HCC have shown remarkable prospects for
solving these complications in HCC owing to their high stability, controlled release, and high drug loading capacity. This review gives an insight into the nano-constructs used for HCC treatment and its active and passive targeting strategies. This review also inculcates the various approaches for targeting the liver cells, its targeting moieties and the conjugation chemistries involved in surface functionalization. A brief description of various therapeutic approaches in the treatment
of HCC has also been discussed.
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Date
2023-07-23
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Publisher
Elsevier
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Keywords
Hepatocellular carcinoma, Liver cancer, Nanocarriers, Targeting ligands, Photothermal therapy, Biosensors