Antimicrobial and anti-biofilm activities of bio-inspired nanomaterials for wound healing applications
Arshad, Rabia Razlansari, Mahtab Hosseinikhah, Seyedeh Maryam Pandey, Aprajita Tiwari Ajalli, Narges Manicum, Amanda-Lee Ezra Thorat, Nanasaheb Rahdar, Abbas Zhu, Yangzhi Tabish, Tanveer A
Arshad, Rabia
Razlansari, Mahtab
Hosseinikhah, Seyedeh Maryam
Pandey, Aprajita Tiwari
Ajalli, Narges
Manicum, Amanda-Lee Ezra
Thorat, Nanasaheb
Rahdar, Abbas
Zhu, Yangzhi
Tabish, Tanveer A
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Abstract
Chronic wounds are ubiquitously inhabited by bacteria, and they remain a challenge as they cause significant discomfort and because their treatment consumes huge clinical resources. To reduce the burden that chronic wounds place upon both patients and health services, a wide variety of approaches have been devised and investigated. Bioinspired nanomaterials have shown great success in wound healing when compared to existing approaches, showing better ability to mimic natural extracellular matrix (ECM) components and thus to promote cell adhesion, proliferation, and differentiation. Wound dressings that are based on bioinspired nanomaterials can be engineered to promote anti-inflammatory mechanisms and to inhibit the formation of microbial biofilms. We consider the extensive potential of bioinspired nanomaterials in wound healing, revealing a scope beyond that covered previously.
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Date
2023-09
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Publisher
Elsevier
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Keywords
Bioinspired nanomaterials, Polymers, Chronic wounds, Biofilms, Targeted delivery, Antimicrobial